Quick answer
Profhilo and Skinvive are hyaluronic acid skinboosters, and NCTF 135HA is hyaluronic acid in a solution with added vitamins, amino acids and other ingredients. All three are on the Malaysian device register, and no trial compares any two. Each has some evidence, mostly maker-linked.
- Profhilo: hyaluronic acid of two molecular weights, 32 mg and 32 mg in 2 mL (Structura 45 mg and 45 mg).
- Skinvive: cross-linked hyaluronic acid at 12 mg/mL with lidocaine, tested in the cheeks.
- NCTF 135HA: free hyaluronic acid in a solution of 53 added components, per a 2015 review.
- Not polynucleotides: Rejuran, Plinest and Newest are a different class, covered in a companion article.
| Product | Type | Contents (register entry) | Trial evidence read | Who ran it |
|---|---|---|---|---|
| Profhilo | Hyaluronic acid, two molecular weights | 3.2%: 32 mg + 32 mg in 2 mL (Structura 4.5%: 45 mg + 45 mg) | 12-woman split-face against saline; effect on thickness did not exceed placebo | University team |
| Skinvive | Cross-linked hyaluronic acid | 12 mg/mL with 0.3% lidocaine, 1 mL | Randomised, 131 treated and 71 controls, cheeks, 6 months | Maker |
| NCTF 135HA | Hyaluronic acid plus added components | Free hyaluronic acid in a buffered NCTF solution | Randomised, 146 people, against cream alone | Maker-funded |
What kind of skin booster is each one?
A skinbooster is a small amount of product placed at many points in the dermis to improve skin quality, and the names sort into groups. Profhilo and Skinvive are hyaluronic acid (HA) products. NCTF 135HA is a cocktail: HA in a solution with other ingredients added. Polynucleotides such as Rejuran are a third group. The article on skinbooster types sets out all three groups and the evidence for each, so this one concentrates on what the three products here contain and what has been tested.
What is in Profhilo, Skinvive and NCTF 135HA?
The Malaysian register describes Profhilo as 3.2% highly purified sodium hyaluronate of two molecular weights, 32 mg of each in a 2 mL syringe. Profhilo Structura is 4.5%, 45 mg of each, and the register says its HA is obtained by biofermentation without chemical modification. Profhilo Body is listed as 48 mg of each in 3 mL.
Skinvive by Juvederm is a gel of cross-linked HA at 12 mg/mL with 0.3% lidocaine in a 1 mL syringe, listed for fine lines and for hydration and elasticity.
NCTF 135 HA is described as free, non-cross-linked HA in a buffered revitalising solution called NCTF, injected by physicians with a multi-injection technique into the face including the eye area, neck, decollete, back of the hands and inner arms. A 2015 review, written with support from the company that markets it, describes NCTF135HA as 53 components, among them vitamins, amino acids, minerals, coenzymes and nucleotides, plus high molecular weight HA. The register gives no amounts for those components.
What do the trials show?
For Skinvive, the US approval study randomised 209 adults to cheek treatment or delayed treatment. In a published report of that trial, 131 treated people and 71 controls were evaluator-blinded, and at month 1 the cheek smoothness and fine-line responder rates were 57.9% and 58.3% against 4.5% and 5.4% in controls. At month 6, 55.6% (69/124) of treated participants were still responders, but controls had been offered treatment by then, so there was no comparison after month 1. The maker ran the study.
For Profhilo, a 2026 triple-blind trial in 12 women compared it with saline on opposite sides of the mouth. Imaging showed fewer wrinkles and smaller pores at 60 days, but the ultrasound thickness of the dermis rose on both sides, and the authors concluded the effect on thickness did not exceed the placebo effect and that patients were not fully satisfied. It is small and covers one area. Disclosure: in September 2026 I received the 2025 IBSA Key Opinion Leader Award; IBSA makes Profhilo.
For NCTF 135HA, a maker-funded randomised trial of 146 people compared three injection sessions plus a cream with the cream alone. At day 75 and day 120 wrinkles in the crow's feet, neck and decollete were reduced more in the injected group, but the control group had no injection, so it cannot separate the product from the needle. A 2026 split-face trial of 52 people found that toxin plus NCTF 135HA reduced wrinkles more than toxin alone, which tests the combination and not NCTF by itself. A 2023 systematic review of 13 studies found HA alone had a more pronounced effect than HA with other ingredients, a comparison made across studies, and called for large randomised trials.
Is one of them better than the others?
No evidence says so. A PubMed search for Profhilo with Skinvive and for Skinvive with NCTF on 21 October 2026 returned no records, and Profhilo with NCTF returned only a laboratory paper, not a clinical comparison. The trials above differ in product, area, comparator and measure, so their figures are not like for like. What differs reliably is the label: the HA concentration, the cross-linking, the added components and the volume.
How these differ from polynucleotide boosters is covered in the companion article on Rejuran, Plinest and Newest. What any skinbooster can and cannot change is in what skinboosters fix, how long they last is in how long skin boosters last, and how the injections feel is in does a skin booster hurt.
Are they registered in Malaysia?
Yes, all three are listed as medical devices on the Medical Device Authority register, which was searched on 21 October 2026 (data updated 20 October). Profhilo, Profhilo Structura and Profhilo Body have separate entries, as do Skinvive by Juvederm and NCTF 135 HA. A register entry shows a device is listed. It does not show that it works for your concern, or that a box is genuine; the article on checking a skinbooster product explains how to match the two.
What should a skinbooster quote state?
A quote is easier to judge when it names the exact product and version (Profhilo or Profhilo Structura, Skinvive, NCTF 135HA), the millilitres per session, the number of sessions, the area, and who injects. Ask for the registration number on the box and check it. The clinic offers skinboosters, and which type suits a given skin is decided at assessment; the skinboosters page explains the treatment.
